EMC missionaries working in church planting and church ministry minister in relationship with the Evangelical Mennonite Conference of Paraguay (Confraternidad Evangélica Menonita del Paraguay, CEMP). The 13 churches within this conference are located in both urban and rural settings in East Paraguay. The president of the CEMP is Julio Martinez, pastor of the Iglesia Central (Center church) in Caaguazú. 

Other missionaries are involved in para-church ministries, such as radio outreach and ministry to people living with HIV/AIDS.